Miguel Azguime studied at the Academia de Amadores de Música (1966-76) and also attended the Lisbon Conservatory. From 1975 to 1982 he studied percussion with Catarina Latino and Júlio Campos and founded various jazz and improvised music groups. In 1984 he went to Darmstadt, where he studied percussion with James Wood and composition with Horatiu Radulescu, Brian Ferneyhough and Clarence Barlow. He also attended seminars with Emmanuel Nunes, Cristóbal Halffter and Tristan Murail. Between 1985 and 1986, he studied percussion with Gaston Sylvestre in Paris and Nice.

In 1985, together with Paula Azguime, he founded the Miso Ensemble, a duo recognised by the public and critics as one of the most important Portuguese contemporary music groups. In addition to numerous concerts in Portugal, the Miso Ensemble has performed regularly abroad, with several hundred concerts to date.

Miguel Azguime has composed music for various formations - instrumental and/or vocal with or without electronics, tape music, sound poetry, as well as music for exhibitions, sound installations, electroacoustic theatre, dance and cinema. His compositional style is part of a language of structural rigour on the one hand and formal freedom on the other. The "mosaic" and "radiant" expressiveness achieved by the richness of timbre, as well as the clarity in the development of ideas, are constant and unifying factors in his music.

Miguel Azguime's works have been performed by renowned soloists, ensembles ( Ensemble Recherche, Norrbotten NEO, Ensemble Ensemble Musikfabrik, Remix Ensemble, BBC Singers, Quarteto de Matosinhos, Sond'Ar-te Electric Ensemble, Smith Quartet, California EAR Unit, etc. ), and conductors ( Laurent Cuniot, Petter Sundkvist, Franck Ollu, Guillaume Bourgogne, Renato Rivolta, Johannes Kalitzke, Pedro Neves, Pedro Carneiro, Pedro Amaral) and performed at the world's main contemporary music festivals (Huddersfield Contemporary Music Festival, MaerzMusik, Warsaw Autumn Festival, Nordic Music Days and Festival Synthèse, among others). The links between the composer "Azguime" and the poet and performer "Azguime" gave rise to a unique text-music relationship, developed in the concept of Electroacoustic Theatre and New Op-Era. The multimedia opera "Itinerário do Sal" (2003/06) is the materialisation of this idea. It is a work that transcends theatrical and musical conventions. Reflecting on art and madness, it revolves around languages, words as sources of meaning and words as sources of sound. Both are used as an extension of the body and fused in the construction of the staging - a tangible projection of the resonance of words through sound and image.

Miguel Azguime has won several composition and performance prizes, for example the EMS composition prize in 2003 for "Le dicible enfin fini", the UNESCO Music Theatre NOW prize for "Salt Itinerary" (2008). He has been composer-in-residence at various electroacoustic music studios around the world, including the Heinrich Stroebel Experimental Studio at Südwestfunk (Freiburg), the EMS Electronic Music Studio (Stockholm), the Centre Henri Pousseur (Liège) and the Department of Sonology at Kunitachi University (Tokyo), among others. He also participates as a jury member in contemporary composition competitions all over the world. In 2006 Miguel Azguime was composer-in-residence at the DAAD in Germany. This context allowed him to create and produce his multimedia opera, "Itinerário do Sal", which is, in a way, the culmination of a process of integration between writing poetry and composing music. This project has also led to a renewed form of creative collaboration within the Miso Ensemble - as a result of the development, implementation and consolidation of joint creative processes involving staging and image. These processes were initiated with Paula Azguime in the works "Yuan Zhi Yuan" and "O Centro do Ecêntrico do Centro do Mundo" from 2002, and more recently in the children's opera "A Menina Gotinha de Água", based on the original poetic tale by Papiniano Carlos, composed for the Children's and Youth Choir of the University of Lisbon in 2010; as well as in the new opera "A Laugh to Cry (2013).